Extended Data Fig. 7: AHR activation boosts DENV replication in vitro.
From: AHR is a Zika virus host factor and a candidate target for antiviral therapy
a, A549 cells were treated with I3S (50 μM) or CH223191 (2 μM) for 24 h. Then, cells were harvested for qPCR analysis of CYP1A1. Data represent the mean ± SD (n = 3 independent experiments). P values were determined by a two-sided Student’s t-test. b, AHR activation boosts DENV replication. A549 cells were pretreated with the indicated concentrations of I3S for 24 h and infected with DENV-2 (MOI = 0.1). 48 h postinfection supernatants were harvested for plaque assay. Data represent the mean ± SD (n = 3 independent experiments). P values were determined by a one-way ANOVA followed by Dunnet’s post-hoc test.
