Extended Data Fig. 4: Learning-related changes in population decoding.
From: Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
a. Relationship between trial-type decoding accuracy and total number of cells (line is mean, shading is ±SD). b. Trial-type decoding accuracy for individual animals during the Late session. (n = 11 vCA1 mice, 5 dCA1, two-sided Mann-Whitney U test vs chance, error bars mean ± SEM). c. Population-activity decoding accuracy for CS+ or CS- trials from baseline.(n = 10 decoding iterations from n-matched of 454 cells from 11 vCA1 and 5 dCA1 mice, two sided Mann-Whitney U test, color coded bar is p < 0.01, line is mean, shading is ±SD). d. Visualization of population activity pattern similarity for CS + and CS- trials via MDS dimensionality reduction. Dot plots show a sample MDS run, bar charts plot the average of 10 runs (n = 10 MDS iterations, two sided Mann-Whitney U test, error bars mean ± SEM). e. Sample cumulative licking during the trace period for CS+ and CS- trials from the Early and second day of learning. The Aha point, in this example at trial 20, represents the first moment the difference between the cumulative licking in CS+ and CS- trials exceeded the learning threshold (see Methods). f. Trial-type decoding accuracy during odor or trace periods using 30 CS+ and CS- trials before and after the Aha point. In vCA1, decoding accuracy significantly increases after the aha point for the odor and trace periods (n = 11 vCA1 5 dCA1 mice, two sided Mann-Whitney U test). Before the aha point, decoding during trace is not significantly different from chance (n = 11 vCA1 5 dCA1 mice, two-sided Wilcoxon test, p > 0.05). In dCA1, aha decoding does not significantly increase during the odor period and increases by a small but significant amount during trace period (n = 11 vCA1 5 dCA1 mice,two sided Mann-Whitney U test). dCA1 trace period decoding before the aha point is already significantly above chance (n = 11 vCA1 5 dCA1 mice, two-sided Wilcoxon test, p < 0.05). Error bars mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001. See Supplementary Table 1 for statistical analysis details.
