Extended Data Fig. 7: Upstream regulators of adDEGs.
From: Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
Regulator modules of adDEGs in 11 cell types. On the left of each heatmap, the first column shows if the regulator is significantly differentially expressed (adDEGs, labeled as DE) or just expressed (exp) in the corresponding cell type. The second column shows the significance of differential expression as represented by the coefficient calculated in MAST analysis. The heatmap shows -log10(p-value) to represent the significance of overlapping targets between regulators by Fisher’s exact test (two-sided).
