Fig. 2: Cortical similarity connectomes: MIND networks and MSNs compared.

a,b, Illustrative MIND network and MSN from the same randomly sampled participant in the ABCD cohort. LH, left hemisphere; RH, right hemisphere; MS, morphometric similarity. c, Cortical surface maps of group mean weighted degree for the MIND networks and MSNs. d, Scatter plot representing the positive correlation between edge weights of the group mean MIND networks and MSNs. e, The distributions of pairwise correlations of network edges between subjects for MIND networks and MSNs, for all pairs of 10,367 subjects. f, The correlation between MIND networks and MSNs constructed using 1–5 additional random features of Gaussian noise (for n = 150 random subjects). The solid line represents mean values, with shading representing empirical 95% confidence interval (CI). g, The fraction of total inter-hemispheric connections represented at different network densities for both group mean MIND networks and MSNs. h, Parcellation consistency of MIND network phenotypes at nodal level (weighted degree) and at edge level. The left plot shows the correlation between weighted degree estimated by each of the possible pairs of three parcellation templates: DK, DK-318 and HCP. To calculate between-parcellation correlations, each vertex was assigned the weighted degree of the region within which it was located, for each parcellation, and the correlation was calculated between the resulting vectors of vertex-wise values. The right plot shows the correlation between 2,278 network edges calculated using the 68-region DK parcellation or by using the finer-grained DK-318 parcellation to estimate 50,403 edges and coarse graining (DK-318 interp.) to match the number of edges in the original DK network. i, The fraction of edges between two regional nodes of the same cytoarchitectonic class over a range of network densities. In g and i, shading represents the 95% CI estimated by population bootstrapping, and the solid line represents the mean over all bootstrapped results. In all panels, except as noted in h, the DK-318 parcellation was used to define 318 cortical regions of approximately equal volume.