Extended Data Fig. 10: Tuning down ACC–VTA–ACC feedback loop relieves hypersensitivity of thermal pain. | Nature Neuroscience

Extended Data Fig. 10: Tuning down ACC–VTA–ACC feedback loop relieves hypersensitivity of thermal pain.

From: An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

Extended Data Fig. 10

a, Statistics of thermal pain behaviors of SNI (nerve ligation removing) (n = 8 mice) vs sham (n = 7 mice), hM4Di vs control virus-injected (in the VTA) SNI mice (with nerve ligation removed), and hM3Dq vs control virus-injected (in the ACC) SNI mice (with nerve ligation removed) 3 weeks after repetitive CNO application (every second day for 2 weeks, n = 6 mice for each). b, Schematic of quinpirole local administration in the ACC (1 µg/µl, 200 nl) of SNI mice. c, Statistics of thermal pain behaviors of SNI mice following the local application of quinpirole vs saline (n = 7 mice for each). d, e, As in (b, c), except that haloperidol (50 µM, 200 nl) was applied in the VTA (saline, n = 7 mice; haloperidol, n = 8 mice). The data are presented as the mean ± s.e.m. Unpaired Student’s t-test, *P < 0.05, **P < 0.01. Detailed statistics information can be found in the Source Data.

Source data

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