Extended Data Fig. 4: Mapping inputs of the spleen in the whole brain. | Nature Neuroscience

Extended Data Fig. 4: Mapping inputs of the spleen in the whole brain.

From: Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Extended Data Fig. 4

a, Schematic diagram for Flouro-Gold (FG) injection into spleens of C57 mice. b, A series of coronal sections, from a representative mouse, showing the distributions of FG signals across different brain areas. Scale bars, 500 μm or 50 μm (zoom). c, Graphs showing the fraction of FG labeled neurons in each brain region that projected to the spleen (n = 5 slice from 3 mice). S1, primary somatosensory cortex; S2, secondary somatosensory cortex; BST, bed nucleus of the stria terminalis; AID, agranular insular cortex, dorsal part; AIV, agranular insular cortex, ventral part; AIP, agranular insular cortex, posterior part; Cl, claustrum; DEn, dorsal endopiriform nucleus; Pir, piriform cortex; S1FL, primary somatosensory cortex, forelimb region; S1BF, primary somatosensory cortex, barrel field; LGP, lateral geniculate nucleus; VP, ventral pallidum; IC, insular cortex; S1DZ, primary somatosensory cortex, dysgranular region; VPM, ventral posteromedial thalamic nucleus; VM, ventromedial thalamic nucleus; ic, internal capsule; MGP, medial globus pallidus; LH, lateral hypothalamic area; ZI, zona incerta; La, lateral amygdaloid nucleus; BLA, basolateral amygdaloid nucleus; LPtA, lateral parietal association cortex; V2, secondary visual cortex; AuD, secondary auditory cortex, dorsal area; cp, cerebral peduncle; STh, subthalamic nucleus; BMP, basomedial amygdaloid nucleus; SC, suprachiasmatic nucleus; V1, primary visual cortex; VTA, ventral tegmental area; SNR, substantia nigra; Ect, ectorhinal cortex; PRh, perirhinal cortex; LEnt, lateral entorhinal cortex; PAG, periaqueductal gray; ECIC, external cortex of the inferior colliculus; PnO, pontine reticular nucleus, oral part; Pr5, principal sensory trigeminal nucleus; 3Cb, 3rd Cerebellar lobule; Sim, simple lobule; PDTg, posterodorsal tegmental nucleus; 6n, root of abducens nerve; 7n, facial nerve or its root; 8vn,vestibular root of the vestibulocochlear nerve; DMV, dorsal motor nucleus of the vagus; NA, ambiguous nucleus; 12N, hypoglossal nucleus. All data are presented as the mean ± SEM.

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