Extended Data Fig. 2: Clustering and experimental variables.

a, Uniform Manifold Approximation and Projection (UMAP) showing ~800 000 nuclei from 87 donors from the orbitofrontal cortex colored by (from left to right) experimental batch, disease status, and sex indicating that clusters were not driven by these parameters. b, Stacked barplots showing the percentage contribution to the respective cell type cluster (from left to right) from experimental batch, disease status and sex. c, UMAP showing ~800 000 nuclei from 87 donors from the orbitofrontal cortex colored by donor. d, Stacked barplot showing the percentage contribution to the respective cell type cluster from each donor.