Extended Data Fig. 6: Description of microglial distribution heterogeneity score. | Nature Neuroscience

Extended Data Fig. 6: Description of microglial distribution heterogeneity score.

From: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19

Extended Data Fig. 6

a. Microglial distribution heterogeneity (MDH) score showing the deviation of microglial numbers measured in given regions within a brain area from the average microglial numbers in that area based on the distribution of Iba1 immunofluorescent profiles. High MDH score indicates high level of distribution heterogeneity (that is marked dislocation of parenchymal microglia). b. Representative images of the lemniscus medialis, oliva inferior and tractus pyramidalis for MDH score measurements (quantification is presented in Fig. 3b). Scale bar: a. 1000 µm, b. 20 µm.

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