Extended Data Fig. 8: Single cell RNA sequencing in the medulla of control and COVID-19 cases. | Nature Neuroscience

Extended Data Fig. 8: Single cell RNA sequencing in the medulla of control and COVID-19 cases.

From: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19

Extended Data Fig. 8

a. Uniform Manifold Approximation and Projection (UMAP) plot of a total of 16260 cells, colored by identified populations (same as Fig. 4a) in control and COVID cases. b. Dot plot showing the expression profile of selected key genes for the identification of all brain cell populations. The dot size corresponds to the fraction of cells within each condition expressing the indicated transcript, and the color indicates average expression. c. SPP1 signaling pathway network analysis. d. Heatmap showing key differential expressed genes for each identified microglia/macrophages cluster. Scale bar represents average scaled gene expression.

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