Extended Data Fig. 5: Comparison of the T-box tandem A-minor latch with the A1492-A1493-G530 latch in the ribosome A site.
From: Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions
a, The A128-A129 latch reinforces the functionally important tRNA (green)-helix A1 (blue) stacking interface. A128 and A129 form a continuous adenosine stack. b and c, The stacked A128 and A129 engage extensive hydrogen bonds with the minor groove, reinforce tRNA-T-box base-pairing and stacking, and “staple” the two RNAs together. d, In the ribosome A site, A1492 and A1493 similarly reinforce the intermolecular codon-anticodon duplex via tandem, stacked A-minor interactions in conjunction with G530. e and f, Hydrogen-bond patterns in the ribosome A site resemble those in the T-box (b and c).
