Extended Data Fig. 3: Aggregate amplification probabilities and size distributions. | Nature Structural & Molecular Biology

Extended Data Fig. 3: Aggregate amplification probabilities and size distributions.

From: Nucleation seed size determines amyloid clearance and establishes a barrier to prion appearance in yeast

Extended Data Fig. 3

A stochastic persistence model of Sup35 aggregate dynamics in vivo determines the probability of amplification of a single Sup35 aggregate as a function of fragmentation rate with Sup35 expression levels (a) at 25% (red), 50% (orange), 100% (teal), 200% (blue) or 400% (purple) or Sup35 aggregate numbers (b) of one (red), two (orange), four (blue) or eight (purple) for [PSI+]Strong with a seed size of five. c, Aggregate size distributions for [PSI+]Strong with a seed size of five (solid black), [PSI+]Weak with a seed size of five (dashed red), or [PSI+]Weak with a seed size of fifteen (solid red) are shown.

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