Extended Data Fig. 5: CD4 binding details in SIVmac239 and HIV-1. | Nature Structural & Molecular Biology

Extended Data Fig. 5: CD4 binding details in SIVmac239 and HIV-1.

From: Cryo-EM structures of prefusion SIV envelope trimer

Extended Data Fig. 5

a, (left) SIVmac239 gp120 from the trimer structure (magenta) is shown aligned to the CD4-bound SIVmac239 gp120 core (gray). (right) SIVmac239 gp120 from the trimer structure (magenta) is shown aligned to an HIV-1 BG505 gp120 from a trimer (light blue). b, (left) The CD4 (yellow) binding site is shown corresponding to the structural alignments in panel a. W427 adjusts out of the pocket that the F43 of CD4 inserts into. (right) Residue 375, used to confer rhCD4 binding to SHIV, is shown in red. Relative positions of W427 in SIV and HIV-1 are shown proximal to the F43 pocket. c, Conformations of the region from residues 50–80 are shown. The region adopts various conformations in SIV and HIV-1 and undergoes a switch upon CD4 binding.

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