Extended Data Fig. 9: Mediator and TFIID are compatible with the PIC-nucleosome structure.
From: Structures of transcription preinitiation complex engaged with the +1 nucleosome
a. Yeast core Mediator (cMed) was placed onto our PIC-nucleosome structure by superimposing the core PIC in the yeast cMed-PIC structure (PDB code: 5OQM)4. b. TFIID was placed onto the PIC-nucleosome structure by superimposing the core PIC in the human TFIID-containing PIC structure (PDB code: 7EGB)6 since no yeast TFIID-containing PIC structure is available. The unmodelled double bromodomain of TAF1 and the PHD finger ___domain of TAF3 are depicted as ovals. The unmodelled histone tails in the structure are depicted as threads with histone modifications symbolized as spheres.
