Fig. 6: Rbp6 NTT occupies the active center cleft of Pol II.
From: Structures of transcription preinitiation complex engaged with the +1 nucleosome
a, Close-up views of Pol II active center in complex A. Pol II subunits are colored and labeled individually. Rpb6 NTT residues are shown as sticks and labeled as indicated. Electrostatic interactions and hydrogen bonds are shown as yellow dotted lines. b, Superposition of the core PIC containing the Rpb6 NTT with the structure of an ITC (PDB 4BBS)27 shows that binding of the NTT is incompatible with nucleic acid binding during transcription. The template strand, nontemplate strand and RNA transcript in the ITC structure are indicated.
