Extended Data Fig. 4: Schematic of Gag processing by HIV-1 protease.
From: HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
The indicated domains of Gag are shown, together with the cleavage products during normal processing. The ΔMA-CANC construct is the starting material used for in vitro assembly and proteolysis experiments throughout this work. The sequential order of proteolytic cleavage and the MW of the cleavage products are shown. The black lines indicate the order of cleavage. Some products are rarely observed under normal conditions, such as ΔMA-CA which represents a species in which SP1, (encoding part of the six helix bundle), is prematurely liberated.
