Extended Data Fig. 4: P1 K49A sperm exhibit less fixed histone retention patterns and altered histone PTMs. | Nature Structural & Molecular Biology

Extended Data Fig. 4: P1 K49A sperm exhibit less fixed histone retention patterns and altered histone PTMs.

From: Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

Extended Data Fig. 4

(a–d) Genome browser tracks of nucleosomes enriched at developmental loci and imprinted genes. (e, f) Quantification of abundance of various histone H3 PTMs retained in P1+/+ and P1K49A/K49A sperm. Each dot represents measurement from a single technical replicate (n = 3 technical replicates per genotype) and each biological sample (n = 1 per genotype) was prepared from a pool of sperm from n = 5 males per genotype. Center line represents the mean and error bars represent standard deviation.

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