Extended Data Fig. 8: Structures of core regions in product disassociation and recycling states during the end of transcription closely resemble the intermediate core of FluPolH5N1. | Nature Structural & Molecular Biology

Extended Data Fig. 8: Structures of core regions in product disassociation and recycling states during the end of transcription closely resemble the intermediate core of FluPolH5N1.

From: An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Extended Data Fig. 8

The secondary structures of catalytic cavities of FluPolH5N1 (in green), FluPol in transcription-product disassociation state (a, PDB: 6T0U, in pink), FluPol in transcription-recycling state (b, PDB: 6T2C, in wheat). Close-up views show the similar conformation of the η7 loop protruding towards the cavity in these core regions. The priming loop in FluPolH5N1 is shown while the priming loops in product disassociation and recycling states are extruded and invisible.

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