Fig. 1: Crystal structure of TRIM72.
From: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
a, Domain organization of TRIM72. Each ___domain and small motif is shown as follows: RING (green); L1 linker, B-box (orange); H1 helix (pink); helix-turn-helix, H2 helix (cyan); L2 linker (mint); H3 helix (yellow); and PRYSPRY (magenta). The residues are numbered based on the mouse TRIM72 sequence. b, Overall structure of mouse TRIM72 represented by a surface model with a ribbon diagram. The color of each ___domain corresponds to the ___domain architecture in a. The second protomer is labeled with a prime symbol (′) and is shown in a less-vibrant color. The structural models were derived from mouse TRIM72 ΔRING (2.75 Å), except for the RING ___domain (green), which came from TRIM72 FL (4.6 Å).
