Extended Data Fig. 6: Structural comparisons of SID-1 and human SIDT1 and SIDT2.
From: Structural insights into double-stranded RNA recognition and transport by SID-1
a and d, Superposition of SID-1 with hSIDT1 (a) and hSIDT2 (d). SID1, hSIDT1, and hSIDT2 are colored in green, pink, and brown, respectively. b and e, Superposition of ECD of SID-1 with ECD of hSIDT1 (b) and ECD of hSIDT2 (e). (c and f) Superposition of TMD of SID-1 with TMD of hSIDT1 (c) and TMD of hSIDT2 (f). g to i, Putative Zn2+ binding site in SID-1 (g), hSIDT1 (h), and hSIDT2 (i). Residues for ion coordinating shown side-chain in sticks. Yellow ball represents a putative Zn2+. EM densities for Zn2+ and key residues are shown in white surface.
