Cell migration is a prerequisite for cancer cell invasion and metastasis. The highlighted study shows that UFMylation of ARPC4 facilitates ARP2/3 complex-mediated lamellipodia formation, thereby promoting cancer cell migration, invasion and metastasis.
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References
Lambert, A. W., Pattabiraman, D. R. & Weinberg, R. A. Cell 168, 670–691 (2017).
Krause, M. & Gautreau, A. Nat. Rev. Mol. Cell Biol. 15, 577–590 (2014).
Zhao, K. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-025-01576-8 (2025).
Komatsu, M. et al. EMBO J. 23, 1977–1986 (2004).
Lappalainen, P., Kotila, T., Jegou, A. & Romet-Lemonne, G. Nat. Rev. Mol. Cell Biol. 23, 836–852 (2022).
Gautreau, A. M., Fregoso, F. E., Simanov, G. & Dominguez, R. Trends Cell Biol. 32, 421–432 (2022).
Lai, W. F. & Wong, W. T. Ageing Res. Rev. 58, 101021 (2020).
Swaney, K. F. & Li, R. Curr. Opin. Cell Biol. 42, 63–72 (2016).
Rotty, J. D., Wu, C. & Bear, J. E. Nat. Rev. Mol. Cell Biol. 14, 7–12 (2013).
Goley, E. D. & Welch, M. D. Nat. Rev. Mol. Cell Biol. 7, 713–726 (2006).
Keenan, E. K., Zachman, D. K. & Hirschey, M. D. Mol. Cell 81, 1868–1878 (2021).
Zhou, X. et al. Trends Biochem. Sci. 49, 52–67 (2024).
Liu, B., Yang, T., Zhang, J. & Li, H. Cell. Signal. 129, 111657 (2025).
He, C. et al. Mol. Cell 84, 1120–1138.e8 (2024).
Komatsu, M., Inada, T. & Noda, N. N. Mol. Cell 84, 156–169 (2024).
Acknowledgements
M.W. and Y.-S.C. are supported by the National Natural Science Foundation of China (U22A20318), Zhejiang Provincial Department of Science and Technology (2023C03166) and Interdisciplinary Research Project of Hangzhou Normal University (2024JCXK06).
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Wang, M., Cong, YS. UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis. Nat Struct Mol Biol (2025). https://doi.org/10.1038/s41594-025-01577-7
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DOI: https://doi.org/10.1038/s41594-025-01577-7
