Figure 2 | Scientific Reports

Figure 2

From: Hydrolysis of Hyaluronic Acid in Lymphedematous Tissue Alleviates Fibrogenesis via TH1 Cell-Mediated Cytokine Expression

Figure 2

Subcutaneous injection of hyaluronidase alleviates lymphedema in a mouse model. At 7 days postsurgery, PBS-injected mice with lymphedema (PBS-LE) and hyaluronidase-injected mice with lymphedema (HYAL-LE) were sacrificed. Cross-sections of the legs with edema were then analyzed. (A,B,C) Representative Masson’s trichrome staining of fibrotic areas. Scale bar = 500 μm. (D,E) Image J analysis of dermal thickness and fibrotic (blue) areas. Data are presented as means ± SEMs. *P < 0.05, **P < 0.005, ***P < 0.001. (F) Schematic diagram of the PBS and hyaluronidase injection schedule. •, hyaluronidase and PBS injection; ■, time of sacrifice.

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