Table 3 Association of blood cadmium level quartiles with hyperuricemia.

From: Cadmium exposure and its association with serum uric acid and hyperuricemia

Variable

CdB level

Q1

Q2

Q3

Q4

P for trend

Men

CdB range, μg/L

≤0.60

0.61–2.09

2.10–4.29

≥4.30

 

Hyperuricemia

 Model adjusted for age, smoking, PbB

Ref.

1.22 (0.82, 1.80)

1.43 (0.96, 2.12)

1.50 (1.00, 2.24)

<0.05

 Full model, overall*

Ref.

1.22 (0.79, 1.87)

1.82 (1.18, 2.79)

1.61 (1.04, 2.49)

<0.05

 Full model, eGFR >60 mL/min per 1.73 m2

Ref.

1.29 (0.82, 2.03)

1.99 (1.26, 3.15)

1.77 (1.11, 2.80)

<0.01

 Full model, non-smoker

Ref.

1.03 (0.58, 1.81)

1.65 (0.94, 2.92)

1.50 (0.85, 2.64)

0.08

Women

CdB range, μg/L

≤0.50

0.51–1.65

1.66–3.88

≥3.89

 

Hyperuricemia

 Model adjusted for age, smoking, PbB

Ref.

0.95 (0.60, 1.51)

1.24 (0.79, 1.94)

1.13 (0.70, 1.83)

0.424

 Full model, overall*

Ref.

1.02 (0.61, 1.70)

1.36 (0.83, 2.22)

1.25 (0.74, 2.11)

0.265

 Full model, eGFR >60 mL/min per 1.73 m2

Ref.

0.98 (0.57, 1.67)

1.11 (0.64, 1.94)

1.11 (0.63, 1.94)

0.642

 Full model, non-smoker

Ref.

1.08 (0.64, 1.81)

1.33 (0.81, 2.20)

1.11 (0.65, 1.90)

0.53

  1. Data are expressed as odds ratios (confidence interval). Logistic regression analyses were used.
  2. eGFR, estimated glomerular filtration rate.
  3. *Full model included eGFR (which incorporates age and serum creatinine level), current smoking status, PbB, diabetes, dyslipidemia, hypertension and BMI. All variables were categorical except eGFR, PbB and BMI, which were entered as continuous measures.