Figure 6

GO enrichment circle plots for the top five most significant GO categories with positive and negative z-score for each treatment adjusted for time. 3R4F 1/30 smoke exposure (A), e-cigarette aerosol exposure at 1/7 (B) and 1/3 (C) dilutions are presented with the statistical filter used to select the genes included in the enrichment. The outer circle shows the relative fold change for each significant RNA feature compared to air contributing to the GO term with blue dots showing down-regulated RNA features and red dots showing up-regulated features. The inner quadrants are colored based on the z-score and their surface is a function of the enrichment p-value, the larger the surface the lower the p-value. The z-score color scale represents the number of up- regulated genes minus the number of down- regulated genes for a given GO term divided by the square root of the total count. The associated tables present the GO term ID and function, p-value for the enriched term, and the number of RNA features contributing to the GO term enrichment.