Figure 5

Overlap between super-enhancers and broad H3K4me3 domains in K562 cells. (a) Histone modifications at proximal regions with both super-enhancers and broad H3K4me3 domains (P_SE_BD), only super-enhancers (P_SE_O), only broad H3K4me3 domains (P_BD_O), and neither (P_O_O). (b) Histone modifications at distal regions with both super-enhancers and broad H3K4me3 domains (D_SE_BD), super-enhancers only (D_SE_O), broad H3K4me3 domains only (D_BD_O), and neither (D_O_O). (c) The fraction of different regions involved in chromatin interactions. (d) Boxplot of number of chromatin interactions each type of regions is involved in. (e) Pairwise comparison of enrichment at oncogenes (OG), tumor suppressor genes (TSG), COSMIC census cancer genes (CCG), and housekeeping genes (HKG) between different distal regions through looping (left), and different proximal regions through looping (middle) and proximity (right). Comparison was performed using Fisher’s Exact Test followed by Holm-Šídák correction for multiple testing. The color indicates the product of negative log-transformed p-values and sign of the log-transformed corresponding odds ratio.