Figure 5
From: NK cell-derived IL-10 is critical for DC-NK cell dialogue at the maternal-fetal interface
IL-10+ NK cells abrogate fetal growth restriction in FLT3 treated IL-10−/− mice. (A) Mean body weights registered in the offspring following FLT3 treatment in IL-10−/− female mice with or without IL-10+/+ NK cells adoptive transfer during early pregnancy. Data shown are mean ± SEM derived from 25–30 fetuses per group. (B) Representative images of fetuses obtained on ED13.5 from FLT3 treated IL-10−/− female mice with IL-10+/+ or IL-10−/− NK cells adoptive transfer; Bar = 0.25 cm. White arrows denote separated fingers on the toes and black arrows indicate the visible hair follicles. (C) Distribution of Theiler stage (TS) of fetal development on ED13.5. Twenty five to thirty fetuses derived from FLT3 treated in IL-10−/− female mice with IL-10+/+ or IL-10−/− NK cells adoptive transfer were scored. The distribution of TS is shown using a pie chart. The percentages of fetuses corresponded to TS20, TS21 and TS22 are indicated for each pie slice. **p < 0.01 analyzed by the Tukey’s test.
