Figure 2
Representative histology and CMR images of a mouse heart subjected to control IRI protocol. (A) Histological staining of transverse slices of mouse heart prepared ex vivo at approximate positions of MR scanning. TTC staining allows identification of MI as area colored off-white (example indicated by arrow). Evans blue staining allows identification of AAR as area not stained blue (example indicated by arrowhead). (B) LGE imaging showing spatially distinct areas of hyper-enhancement in areas of MI (example indicated by arrow). (C) T2-mapping showing spatially distinct areas of elevated T2 (ms) (yellow-red appearance) compared to normal region (dark blue color). (D) ASL perfusion mapping showing spatially distinct areas of decreased perfusion (ml/g/min) (dark blue appearance) compared to normal region (yellow-red color). (E) T1-mapping showing spatially distinct areas of elevated T1 (s) (yellow-red appearance) compared to normal region (dark blue color). Histology and MR images have different slice thicknesses and cardiac contraction states and therefore should not be compared slice-by-slice.
