Figure 5

Time course of TQ/SQ during perfusion protocol. The plot is separated into bolus invasion, perfusion stop and reperfusion. Additionally, the data have been normalized to the mean value of TQ/SQ intensity during bolus invasion. The black solid line represents data of the control experiment. Strophanthin experiments are depicted with the red lines. All time courses show an oscillatory behavior prior to perfusion interruption. At 60 min all curves reach their maximum intensity (first red bar). After a drop in intensity at 72 min all curves reach their minimum value (second red bar). Curves recorded from strophanthin induced experiments show a markedly lower drop compared to the control experiment. This is followed by a relaxation period which seems not to be affected by reestablishing perfusion. It can be seen that the difference in signal loss between bolus invasion and reperfusion period is more pronounced in the strophanthin curves than in the control experiment. Oscillations do not occur during perfusion interruption and reperfusion.