Table 1 Body weight, food intake and serum metabolites levels in mice fed either the control diet or obesogenic diets (high-sugar (HS), high-fat (HF) and high-sugar/high-fat (HSHF)) for eight weeks.

Initial body weight (g)

26.0 ± 0.67

25.0 ± 0.55

27.0 ± 0.70

25.0 ± 0.57

Body weight gain (g)

1.9 ± 0.42

9.9 ± 0.98^a

8.9 ± 1.10^a

17.5 ± 1.41^a,b,c

Food ingestion (g/week)

177.2 ± 7.13

130.2 ± 4.86^a

102.7 ± 1.17^a,b

82.1 ± 1.66^a,b,c

Condensed milk intake (g/week)

—

74.8 ± 4.67

—

51.8 ± 6.57^b

Caloric ingestion (kcal/week)*

673.7 ± 27.01

738.0 ± 15.99

548.5 ± 6.25^a,b

606.8 ± 24.66^a,b,c

Visceral adipose tissue (g)

0.64 ± 0.19

1.3 ± 0.24^a

1.7 ± 0.41^a

2.0 ± 0.26^a,b

Liver weight (g)

1.2 ± 0.04

1.8 ± 0.15^a

1.8 ± 0.13^a

2.0 ± 0.12^a

Total cholesterol (mg/dL)

137.0 ± 7.42

186.0 ± 5.84^a

201.0 ± 7.82^a

207.0 ± 8.52^a

LDL-cholesterol (mg/dL)

85.0 ± 7.30

100.0 ± 4.27

140.0 ± 9.37^a,b

114.0 ± 6.72^a

Triacylglycerol (mg/dL)

62.0 ± 5.90

56.0 ± 3.41

66.0 ± 4.25

72.0 ± 3.29

AST (U/L)

13.8 ± 1.25

31.2 ± 4.23^a

18.9 ± 2.39

25.1 ± 4.32

Fasted** serum glucose (mg/dL)

163.0 ± 7.84

190.0 ± 6.83

240.0± 13.64^a,b

214.0 ± 13.49^a

Fasted** serum insulin (ng/mL)

0.3 ± 0.03

1.1 ± 0.12

1.2 ± 0.25

2.4 ± 0.45^a,b,c

Glucose intolerance (AUC)

8154 ± 840.6

14209 ± 1305^a

14409 ± 1372^a

18574 ± 1377^a

Insulin sensitivity (kITT - %/min)

3.5 ± 0.25

3.1 ± 0.20

3.7 ± 0.28

2.2 ± 0.21^a,b,c