Figure 6 | Scientific Reports

Figure 6

From: E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer

Figure 6

RAD51-AS1 knockdown impairs tumor growth in vivo. (A), Growth curves of xenograft tumors. Tumor growth in the RAD51-AS1-knockdown group was substantially slower than that in control group, and the gap between the two groups increased over time. (B), Visual comparison of the tumors in the RAD51-AS1-knockdown group and the control group. (C) The efficiency of RAD51-AS1 silencing in vivo was validated by qRT-PCR. (D), The tumor weight in the RAD51-AS1 knockdown group was significantly decreased compared with the controls. (E), Xenograft tumor tissue sections were stained with hematoxylin-eosin-saffron (HE). Representative images of immunohistochemical staining for Ki67, CCNE2, PH3, CASP3, CASP9, p53 are shown. (F). Statistical analysis of the IHC experiments. (*P < 0.05; **P < 0.01; ***P < 0.001 with Student’s t test).

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