Figure 1
From: Multiplication rate variation in the human malaria parasite Plasmodium falciparum
Measurement of exponential multiplication rates of laboratory adapted clones of P. falciparum. (A) 6-day growth assays for four laboratory clones, showing parasite density as numbers of genome copies per microlitre (on a log10 scale). Six biological replicates were performed using different donor erythrocytes. Estimation of parasite copy numbers by quantitative PCR was confirmed to be highly correlated with counts of parasites by microscopy of Giemsa-stained slides (Supplementary Figure S1). ‘3D7’ here refers to the genetically modified clone 3D7-HT-GFP35 whereas the other clones were not genetically modified. (B) General linear model estimates of the replication rates per 48 hours over the 6-day assays for each of the four laboratory clones (point estimates with 95% confidence intervals).
