Figure 6
From: Strategies to Mitigate Variability in Engineering Human Nasal Cartilage
(a,c) Interaction index identifying chondro-induction in co-culture for both normoxia (top) and hypoxia (bottom) for all 5 donors. Black bars are nasal chondrocytes, white bars are co-culture and grey is the expected value from the NC and BM-MSC without any interaction. CC values higher than expected values indicated a chondro inductive effect. (b) Relative gene expression for COL10A1 for the groups NC, CC and MSC in normoxia (NRX) and hypoxia (HYP) normalized against YHWAZ. (d) Regression of GAG/DNA vs gene expression of FGFR1, showing a positive and significant correlation, R2 = 0.66, adjusted p < 0.05.
