Figure 1
Serum concentrations of four proteins in patients with different disorders and HCs. Abbreviations: SZ, schizophrenia paranoid type; MDD, major depressive disorder; BM, bipolar mania; BD, bipolar depression; PD, panic disorder; HCs, healthy controls; tPA, tissue plasminogen activator; proBDNF, precursor brain-derived neurotrophic factor; TrkB, tropomyosin-related kinase B; p75NTR, neurotrophin receptor p75. Compared with HCs group by Kruskal-Wallis test followed by Dunnett T3 test, *P < 0.05, **P < 0.01. Compared with PD group by Kruskal-Wallis test followed by Dunnett T3 test, # P < 0.05, ## P < 0.01. Several extreme values which below the minimum detectable concentration of the kit or higher than three standard deviations were removed out from tPA, proBDNF, TrkB and p75NTR. After removing out the extreme values, the remaining number of cases showed as follows: tPA (33 SZ, 30 MDD, 29 BM, 22 BD, 30 PD and 30HCs), proBDNF (32 SZ, 28 MDD, 29 BM, 21 BD, 28 PD and 28 HCs), TrkB (33 SZ, 29 MDD, 29 BM, 21 BD, 29 PD and 29 HCs), p75NTR (27 SZ, 26 MDD, 23 BM, 19 BD, 25 PD and 27 HCs). Finally, 27 SZ, 25 MDD, 22 BM, 19 BD, 24 PD patients and 25 HCs had all the four proteins.
