Table 1 Characteristics of the participants.

From: Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial

Variables

Males

Females

Non-diabetics

NOD

P

Non-diabetics

NOD

P

N

5399

657

 

7850

958

 

Age, years

61.2 ± 7.4

61.4 ± 7.4

0.490

59.1 ± 7.3

59.8 ± 7.3

0.012

Angiotensin-converting enzyme inhibitor, n (%)

5399 (100.0)

657 (100.0)

—

7850 (100.0)

958 (100.0)

—

Treatment group, n (%)

  

0.319

  

0.905

    Enalapril

2708 (50.2)

316 (48.1)

 

3941 (50.2)

479 (50.0)

 

    Enalapril-folic acid

2691 (49.8)

341 (51.9)

 

3909 (49.8)

479 (50.0)

 

Clinical center, n (%)

  

0.420

  

0.146

    Anqing

1569 (29.1)

181 (27.5)

 

1778 (22.6)

237 (24.7)

 

    Lianyungang

3830 (70.9)

476 (72.5)

 

6072 (77.4)

721 (75.3)

 

Smoking status, n (%)

  

0.524

  

0.009

    Never

1633 (30.3)

197 (30.0)

 

7534 (96.0)

899 (93.9)

 

    Ever

869 (16.1)

117 (17.8)

 

83 (1.1)

15 (1.6)

 

    Current

2896 (53.6)

343 (52.2)

 

228 (2.9)

43 (4.5)

 

Alcohol, n (%)

  

0.041

  

0.263

    Never

1869 (34.6)

211 (32.1)

 

7296 (93.0)

901 (94.1)

 

    Ever

679 (12.6)

105 (16.0)

 

212 (2.7)

26 (2.7)

 

    Current

2850 (52.8)

341 (51.9)

 

333 (4.2)

30 (3.1)

 

BMI, kg/m2

24.0 ± 3.3

25.0 ± 3.7

<0.001

25.2 ± 3.7

26.5 ± 4.0

<0.001

SBP, mmHg

165.4 ± 20.3

166.2 ± 21.4

0.317

167.8 ± 20.1

169.4 ± 20.8

0.022

DBP, mmHg

95.5 ± 12.3

95.6 ± 12.5

0.807

93.3 ± 11.4

93.8 ± 11.3

0.254

TG, mmol/l

1.5 ± 0.9

1.8 ± 1.4

<0.001

1.7 ± 0.8

2.0 ± 3.2

<0.001

HDL, mmol/l

1.4 ± 0.4

1.3 ± 0.4

0.002

1.3 ± 0.3

1.3 ± 0.3

<0.001

TC, mmol/l

5.3 ± 1.1

5.4 ± 1.2

0.019

5.6 ± 1.2

5.6 ± 1.2

0.794

FPG, mmol/l

5.3 ± 0.7

5.7 ± 0.8

<0.001

5.4 ± 0.6

5.8 ± 0.7

<0.001

Crea, μmol/L

76.5 ± 16.9

74.3 ± 14.4

0.002

58.7 ± 11.9

57.6 ± 11.5

0.006

Folate, median (IQR), pg/ml

7.1 (0.7–49.1)

6.9 0.9–21.8)

0.460

8.5 (1.4–67.8)

8.1(2.7–38.7)

0.006

B12, median (IQR), μmol/L

370.3(39.6–2947.5)

374.2(92.7–1644.5)

0.363

377.3(9.9–4467.0)

380.8(69.3–1939.7)

0.147

Hcy, median (IQR), μmol/l

14.1 (3.0–142.3)

14.3 (5.0–119.4)

0.864

11.4 (3.5–113.5)

11.6 (5.1–52.6)

0.894

MTHFR C677T, n (%)

  

0.157

  

0.386

    CC

1515 (28.1)

176 (26.8)

 

2141 (27.3)

260 (27.1)

 

    CT

2644 (49.0)

308 (46.9)

 

3901 (49.7)

459 (47.9)

 

    TT

1240 (23.0)

173 (26.3)

 

1808 (23.0)

239 (24.9)

 
  1. Continuous variables are presented as mean ± SD or median (IQR), while categorical variables are presented as n (%).
  2. Abbreviations: SBP = systolic blood pressure, DBP = diastolic blood pressure, TG = triglycerides, HDL = high-density lipoprotein, TC = total cholesterol, FPG = fasting plasma glucose, HCY = homocysteine, BMI = body mass index, NOD = new-onset diabetes; MTHFR = methylenetetrahydrofolate reductase.
Back to article page