Table 6 Subgroup analysis of NOD risk associated with TG/HDL according to important covariates by logistic regression.

From: Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial

Subgroups

Continuous

Categories

P for interaction

Events, n (%)/N

OR (95%CI)

P value

P for interaction

Normal

Abnormal

OR (95%CI)

P value

Events, n (%)/N

Events, n (%)/N

Age

   

0.527

    

0.833

    <60

777 (10.4)/7648

1.12 (1.06, 1.18)

<0.001

 

682 (9.9)/6889

95 (16.4)/579

1.45 (1.13, 1.86)

0.004

 

    ≥60

838 (11.3)/7396

1.15 (1.07, 1.23)

<0.001

 

755 (10.9)/ 6943

83 (18.3)/453

1.47 (1.13, 1.92)

0.004

 

Center*

   

0.028

    

0.007

    Anqing

418 (11.1)/3765

1.18 (1.09, 1.28)

<0.001

 

370 (10.4)/3560

48 (23.4)/205

2.19 (1.50, 3.18)

<0.001

 

    Lianyungang

1197 (10.8)/11,099

1.10 (1.05, 1.16)

<0.001

 

1067 (10.4)/10272

130 (15.7)/827

1.30 (1.06, 1.61)

0.013

 

Gender

   

0.498

    

0.553

    Males

657 (10.8)/6056

1.11 (1.04, 1.18)

0.001

 

581 (10.3)/5653

76 (18.9)/403

1.58 (1.19, 2.10)

0.002

 

    Females

958 (10.9)/8808

1.14 (1.07, 1.21)

<0.001

 

856 (10.5)/8179

102 (16.2)/629

1.46 (1.22, 1.75)

<0.001

 

Group

   

0.790

    

0.890

    Enalapril

795 (10.7)/7444

1.12 (1.05, 1.20)

<0.001

 

707 (10.2)/6937

88 (17.4)/507

1.44 (1.11, 1.87)

0.006

 

    Enalapril-folic acid

820 (11.1)/7420

1.14 (1.07, 1.21)

<0.001

 

730 (10.6)/6895

90 (17.1)/525

1.50 (1.16, 1.93)

0.002

 

Smoke status

   

0.544

    

0.318

    Never

1096 (10.7)/10,263

1.11 (1.05, 1.17)

<0.001

 

979 (10.3)/9530

117 (16.0)/733

1.39 (1.11, 1.73)

0.003

 

    Ever

132 (12.2)/1084

1.13 (0.95, 1.35)

0.163

 

118 (11.8)/1001

14 (16.9)/83

1.26 (0.65, 2.42)

0.492

 

    Current

386 (11.0)/3510

1.16 (1.07, 1.26)

<0.001

 

339 (10.3)/3294

47 (21.8)/216

1.79 (1.23, 2.60)

0.002

 

Drink status

   

0.374

    

0.942

    Never

1112 (10.8)/10,277

1.14 (1.08, 1.20)

<0.001

 

987 (10.4)/9528

125 (16.7)/749

1.44 (1.16, 1.78)

0.001

 

    Ever

131 (12.8)/1022

1.25 (1.04, 1.50)

0.015

 

115 (12.2)/945

16 (20.8)/77

1.51 (0.79, 2.86)

0.216

 

    Current

371 (10.4)/3554

1.09 (1.01, 1.17)

0.023

 

334 (10.0) 3348

37 (18.0)/206

1.57 (1.05, 2.35)

0.028

 

BMI

   

0.743

    

0.750

    <24

523 (8.3)/6283

1.12 (1.02, 1.23)

0.017

 

505 (8.3)/ 6102

18 (9.9)/ 181

1.29 (0.78, 2.14)

0.320

 

    ≥24, <28

643 (11.1)/5786

1.14 (1.07, 1.22)

<0.001

 

566 (10.6)/ 5322

77 (16.6)/ 464

1.55 (1.18, 2.03)

0.001

 

    ≥28

448 (16.1)/2790

1.14 (1.06, 1.23)

<0.001

 

365 (15.2)/ 2403

83 (21.4)/ 387

1.56 (1.17, 2.08)

0.003

 

SBP, mmHg

   

0.220

    

0.765

    <140

90 (10.6)/853

1.24 (1.02, 1.50)

0.028

 

77 (9.7)/ 794

13 (22.0)/ 59

1.99 (0.94, 4.25)

0.074

 

    ≥140, <160

495 (10.4)/4759

1.14 (1.06, 1.24)

<0.001

 

440 (9.9)/ 4433

55 (16.9)/326

1.36 (0.98, 1.90)

0.068

 

    ≥160, <180

595 (10.5)/5691

1.07 (0.99, 1.14)

0.072

 

535 (10.1)/ 5311

60 (15.8)/380

1.36 (1.00, 1.85)

0.048

 

    ≥180

435 (12.2)/3561

1.16 (1.07, 1.26)

0.001

 

385 (11.7)/ 3294

50 (18.7)/267

1.62 (1.15, 2.28)

0.006

 

DBP, mmHg

   

0.934

    

0.268

    <90

531 (10.9/4882

1.14 (1.05, 1.24)

0.001

 

481 (10.5)/ 4583

50 (16.7)/ 299

1.35 (0.96, 1.89)

0.090

 

    ≥90, <100

551 (10.8)/5125

1.11 (1.03, 1.20)

0.006

 

498 (10.4)/ 4782

53 (15.5)/343

1.25 (0.90, 1.72)

0.185

 

    ≥100, <110

368 (10.9)/3390

1.11 (1.01, 1.22)

0.023

 

320 (10.2)/ 3123

48 (18.0)/267

1.58 (1.11, 2.26)

0.011

 

    ≥110

165 (11.2)/1467

1.16 (1.04, 1.28)

0.005

 

138 (10.3)/1344

27 (22.0)/123

2.39 (1.45, 3.95)

0.001

 

Folic acid, ng/ml

   

0.781

    

0.094

    <8.1

860 (11.5)/7510

1.11 (1.05, 1.18)

0.001

 

759 (11.0)/6886

101 (16.2)/ 624

1.27 (1.00, 1.61)

0.050

 

    ≥8.1

746 (10.3)/7233

1.13 (1.06, 1.20)

<0.001

 

670 (9.8)/6836

76 (19.1)/397

1.77 (1.33, 2.34)

<0.001

 

Hcy, μmol/l

   

0.237

    

0.495

    <10

305 (10.4)/2944

1.08 (1.00, 1.16)

0.042

 

271 (10.0)/2719

34 (15.1)/225

1.26 (0.83, 1.90)

0.274

 

    ≥10

1310 (11.0)/11,914

1.15 (1.09, 1.21)

<0.001

 

1166 (10.5)/11110

144 (17.9)/804

1.53 (1.25, 1.87)

<0.001

 

MTHFR C677T

   

0.119

    

0.579

    CC

436 (10.7)/4092

1.09 (1.02, 1.17)

0.014

 

391 (10.2%)/3825

45 (16.9%)/267

1.39 (0.97, 1.99)

0.074

 

    CT

767 (10.5)/7312

1.17 (1.10, 1.25)

<0.001

 

677 (10.0%)/6799

90 (17.5%)/513

1.59 (1.22, 2.05)

0.001

 

    TT

412 (11.9)/3460

1.07 (0.97, 1.17)

0.170

 

369 (11.5%)/3208

43 (17.1%)/252

1.33 (0.92, 1.92)

0.127

 
  1. SBP = systolic blood pressure, DBP = diastolic blood pressure, TG = triglycerides, HDL = high-density lipoprotein, TC = total cholesterol, HCY = homocysteine, NOD = new-onset diabetes, MTHFR = methylenetetrahydrofolate reductase.
  2. *Clinical center represents two rural areas in Anhui and Jiangsu provinces in China.
  3. Adjusted for age, gender, clinical center, SBP, DBP, smoking and drinking status, baseline FPG, and BMI, if not stratified.
  4. Only TG levels were analyzed because of colinearity with TC and HDL.
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