Figure 2 | Scientific Reports

Figure 2

From: Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in mice

Figure 2

Expression of soluble epoxide hydrolase (sEH) in white matter of normal and hypoperfusion injured brain. (A) Double immunofluorescent staining of sEH (red), CD31/NG2/Iba1/GFAP (green), and merge of CD31/NG2/Iba1/GFAP and sEH in the corpus callosum (CC) section. Scale bar represents 20 μm. (B) Immunofluorescence of sEH in the CC of mice in sham and bilateral carotid artery stenosis (BCAS) group from days 3 to weeks 8 after operation. Scale bar represents 20 μm. (C) Representative western blots of sEH and β-actin expression in the CC of sham and BCAS mice at 4 weeks after operation. (D) Statistical analysis of western blots of sEH in the CC of sham and BCAS mice, n = 5/group. (E) Representative western blots of sEH and β-actin expression in the CC of sham, vehicle and TPPU treatment groups at 4 weeks after operation. (F) Statistical analysis of western blots of sEH in the CC of sham, vehicle, and TPPU treatment groups at 4 weeks after operation, n = 5/group. Values are expressed as mean ± SEM. *P < 0.05, **P < 0.01, vs sham group. # P < 0.05, ## P < 0.01, vs vehicle group.

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