Figure 7
TPPU enhances Oligodendrogenesis and promotes differentiation of oligodendrocytes after bilateral carotid artery stenosis (BCAS). (A) Representative image showing the colocalization of bromodeoxyuridine (BrdU; green) and NG2/olig2/GST-π (red) staining in the corpus callosum (CC) of mice in sham, vehicle and TPPU treatment groups at 4 weeks after operation. Scale bar represents 50 μm. (B–D) Numbers of NG2 labeled oligodendrocyte progenitor cells (OPCs), olig2 labeled the oligodendrocyte (OL) lineage cells and GST-π labeled mature OLs in the CC were expressed as cells/mm2, n = 5/group. (E–G) Numbers of BrdU/NG2-dual labeled OPCs, BrdU/olig2-dual labeled the OL lineage cells, and BrdU/ GST-π labeled mature OLs in CC areas were expressed cells/mm2, n = 5/group. Values are expressed as mean ± SEM. *P < 0.05, **P < 0.01, vs sham group. # P < 0.05, ## P < 0.01, vs vehicle group.
