Figure 2 | Scientific Reports

Figure 2

From: Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

Figure 2

Proposed functional rotation mechanism of substrate extrusion by RND transporters. (a) Top view illustrating the different conformations assumed by AP, DP and Exit Gate (EG) during the three cycles of the functional rotation mechanism. The substrate (orange) is represented by van der Waals spheres and its pathway along the cycle is indicated by short black arrows. The key regions housing the substrate are coloured dull when binding to the substrate, bright otherwise. (b) Front view of the putative substrate transport pathway from AP to EG going through DP. The pathway is shown as thick tube, coloured in blue and magenta for the stages of the transport cycle associated to the Loose→Tight and Tight→Open conformational changes, respectively. The substrate is represented by sticks coloured green, red and iceblue when interacting with the AP, DP and EG (also coloured green, red and iceblue), respectively. The G-loop separating AP and DP is shown as a yellow cartoon.

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