Table 1 Antibiotic substrate specificities of the paralog RND transporters AcrB and AcrD from E. coli22, 25, 46, 80,81,82,83,84.

From: Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

Transporter(s)

AcrB

AcrD

AcrB and AcrD

Antibiotic substrates

Macrolides (erythromycin), chloramphenicol, Fluoroquinolones (ciprofloxacin), Tetracyclines (tetracycline, tigecycline, minocycline), doxorubicin, acriflavine

Aminoglycosides (amikacin, gentamicin, kanamycin, neomycin)

Most beta-lactams (aztreonam, sulbenicillin), Aminocoumarins (novobiocin)

  1. Classes of compounds are indicated, with examples of specific compounds within parentheses (2D chemical structures of these compounds are shown in Supplementary Figure S3).
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