Figure 4
From: Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
Effects of ApoB-ASO-T3 (AAT3) on LDL levels. (a) Apolipoprotein B (ApoB) mRNA levels in liver. (b) Serum LDL levels. AA: ApoB-ASO. n = 5–6 per group; *p < 0.05 vs controls, #p < 0.05 vs AA. (c) Schematic working model for ASO-T3 action. ASO-T3 is internalized and processed in cells. ASO knocks down the target gene and T3 exerts its biological functions by activating nuclear thyroid hormone receptor.
