Figure 4

Co-variance network of bacterial genera and metabolic pathways with statistically significant difference in abundance between FC and HS subjects. Panel a shows a force-driven network based on the predicted co-variances with p-values < 0.05 between the genera and metabolic pathways identified as statistically altered in FC as compared to HS. Panel b reports a force-driven network based on the predicted co-variances with p-values < 0.05 between genera and metabolic pathways putatively involved in FC development. Co-variances with p-values < 0.05 are used to define the attractive or repulsive force of the edges. The node size is proportional to the number of co-variances. Node color indicates phylum or pathway category as reported in the image. The taxonomy, i.e. bacterial genera, of the nodes is indicated with number, as listed in the table.