Figure 1
From: TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia
Learning and memory was enhanced in TREM2 TG mice, but TREM2 KO mice showed a tendency toward defects. (A) Motor behavior was analyzed using the rotarod test in TREM2 TG mice (n = 8) and WT littermates (n = 8) as described in the Methods section. (B) Representative traces of swimming plots in the Morris water maze test of TREM2 TG and WT littermates. (C) Bar graphs calculated from data obtained from the Morris water maze test. Visible trial 4 is the last visible platform trial on day 1 before testing, representing the baseline. During testing on day 2, the time spent by each mouse before arriving at the hidden platform during trial 1 (hidden trial 1) was measured as the escape latency. (D) Rotarod test in TREM2 KO (n = 6) and WT littermates (n = 7). (E) Plots of swimming traces in TREM2 KO and WT littermates. (F) Bar graphs calculated from data obtained from the Morris water maze test. Data are presented as the mean ± SEM. One-way analysis of variance with Tukey’s post hoc multiple comparisons test was performed for all statistical analyses (*p < 0.05; other comparisons were not significant).
