Figure 6
From: A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma
Compound 8a prevented Mch-induced AHR in asthmatic mice. NaCl: NaCl-sensitized and -challenged mice. OVA: OVA-sensitized and -challenged mice. OVA/vehicle: asthmatic mice treated with vehicle. OVA/BUD-5 mg: asthmatic mice treated with 5 mg budesonide. OVA/compound 8a-0.2 mg, 1 mg and 5 mg: asthmatic mice treated with 0.2, 1 or 5 mg compound 8a. n = 6–9 mice per group. Error bars show mean ± SEM. *p < 0.05 by comparison with OVA group treated with vehicle.
