Figure 8

Compound 8a reduced inflammatory infiltrates and goblet cell metaplasia in asthmatic mice. (a) Effects of compound 8a on airway and lung inflammation. Scalar bars, 200 μm. (b) Effects of compound 8a on airway mucus production. Scalar bars, 100 μm. Lung tissues were stained with hematoxylin/eosin (H&E) or periodic acid-Schiff (AB/PAS), and the stained sections were scored. NaCl: 0.9% NaCl-sensitized and -challenged mice. OVA: OVA-sensitized and -challenged mice. OVA/vehicle: asthmatic mice treated with vehicle of 0.5% DMSO dissolved in the saline. OVA/BUD-5 mg: asthmatic mice treated with 5 mg budesonide. OVA/compound 8a-0.2 mg, 1 mg and 5 mg: asthmatic mice treated with 0.2, 1 or 5 mg compound 8a. n = 6 mice per group. Error bars show mean ± SEM. *p < 0.05, **p < 0.01 by comparison with OVA group treated with vehicle.