Figure 4

Clinical seizure types occurring at 2, 3, 4, and 6 weeks following intrahippocampal kainate injection in mice and effect of treatment with a combination of NBQX and ifenprodil during the latent period of this model. Data are combined from experiments 2 and 3 (see Fig. 1). In each graph, the number of clinical seizures in individual mice is shown; the group median is indicated by the horizontal line. Seizures are differentiated into focal (stage I-III) and generalized (stage IV and V) seizures. Analysis of data by two-way ANOVA indicated a significant difference between vehicle and drug treated groups (P = 0.0381); post hoc analysis by Dunn’s multiple comparisons test indicated that drug treatment significantly reduced seizure frequency at 2 weeks after kainate (P = 0.0051).