Table 4 Average DTED of tensors over all pairs of datasets used in T1_normalized, FA_normalized, and hFA_normalized.

Brain Region	F_Anormalized × 10⁻⁴		T1_normalized × 10⁻⁴		hFA_normalized × 10⁻⁴		F	P	P1	P2	P3
Brain Region	mean	STD	mean	STD	mean	STD	F	P	P1	P2	P3
ALIC	2.147	0.418	2.532	0.401	2.614	0.413	59.417	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰
CG	2.041	0.359	3.338	0.437	3.813	0.570	98.674	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰
EC	1.998	0.334	2.446	0.416	2.562	0.820	385.748	<10⁻¹⁰	<10⁻¹⁰	0.013	<10⁻¹⁰
fornix	7.355	0.975	7.453	1.450	8.042	0.292	43.742	<10⁻¹⁰	0.0003	0.004	<10⁻¹⁰
GCC	4.419	2.447	4.432	1.352	4.504	2.468	2.174	0.227	—	—	—
PLIC	2.365	0.287	2.719	0.280	2.922	0.597	162.217	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰10⁻¹⁰
SCC	3.376	1.811	4.539	0.954	4.983	3.075	278.081	<10⁻¹⁰	0.187	<10⁻¹⁰	<10⁻¹⁰
CST	2.477	0.735	2.830	0.434	3.101	0.743	546.853	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰
SLF	3.494	0.797	3.567	0.645	3.813	0.519	54.659	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰
IFOF	2.057	0.642	2.627	0.322	2.909	0.742	100.459	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰	<10⁻¹⁰

ALIC: anterior limb of the internal capsule, CG: cingulum, EC: external capsule, fornix, GCC: genu of the corpus callosum, PLIC: posterior limb of the internal capsule, SCC: splenium of the corpus callosum, CST: corticospinal tract, SLF: superior longitudinal fascicle, IFOF: inferior fronto-occipital fasiculus. DTED: Euclidean distance of tensors. ANOVA was used to compare the difference between the three diffusion tensor templates. P1: Statistically significant differences between FA_normalized and T1_normalized (after correction for multiple comparisons with the Bonferroni approach). P2: Statistically significant differences between T1_normalized and hFA_normalized (after correction for multiple comparisons with the Bonferroni approach). P3: Statistically significant differences between FA_normalized and hFA_normalized (after correction for multiple comparisons with the Bonferroni approach).

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