Figure 1 | Scientific Reports

Figure 1

From: Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy

Figure 1

Human mesenchymal stem cells phagocytose Mycobacterium tuberculosis (H37Rv). (a) Mesenchymal stem cells (MSCs) (fluorescent phase contrast images shown) were purified from human bone marrow (H-BM-MSC; aka BM-MSC) or umbilical cord (H-UC-MSC) and infected with virulent gfp labeled Mycobacterium tuberculosis (gfpMtb) for 4 hr and washed, and the percentage of cells with intracellular bacteria analyzed using microscopy (white bar = 5 µM). (b) Quantification of Mtb uptake by BM-MSCs compared with mouse (M) phagocytes purified from the bone marrow of C57Bl/6 mice, human (H) THP-1 macrophages, A549 human lung epithelial cell line and HeLa cells.

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