Figure 2

Association signals around novel lead variants. The x-axis represents chromosomal positions and the y-axis represents −log10 P-values. The lead variant is shown in purple. Colours represent the degree of LD (r 2) between each variant and the lead variant. The LD (r 2) was calculated based on the combined dataset of Iwate and Miyagi subjects. (a) The TMC6–TMC8 locus. Lead variant was rs2748427. (b) The SIX3–SIX2 locus. Lead variant was rs10168523.