Figure 6 | Scientific Reports

Figure 6

From: All-trans retinoic acid enhances cytotoxicity of CIK cells against human lung adenocarcinoma by upregulating MICA and IL-2 secretion

Figure 6

CIK combined with ATRA treatment inhibited tumor growth of A549 cells in vivo. (A) Tumor Volume curve and (B) Tumor weight graph. 20 mice were randomly divided into 5 groups: (1) control group (0.9% NS, 10 ml/kg), (2) cis-platinum (CDDP) group (2 mg/kg), (3) CIK group (1.0 × 107), (4) ATRA group (5 μmol/kg). (5) CIK + ATRA group. Human A549 cells, about 5 × 106 in 0.2 ml PBS, were s.c. injected into the right-side flank area of each mouse. After treatment, tumour volumes and weights of mice in each group were determined. *p < 0.05,**p < 0.01 compared with the control group, respectively. Δ p < 0.01 compared with CIK or ATRA group.

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