Figure 1
From: A Novel Human Systemic Lupus Erythematosus Model in Humanised Mice
Increased mortality and production of human anti-nuclear autoantibodies in pristane-injected hu-mice. (a) Survival curve of hu-mice (left) and NSG (right), with or without pristane injection, as indicated, was monitored for 20 weeks after treatment. Figure shown is from three independent experiments (control n = 19; pristane n = 24; NSG control n = 9; NSG pristane n = 9). (b) Level of human anti-nuclear autoantibodies in blood plasma were measured by ELISA at 8 weeks post-pristane injection in hu-mice. Control group represents data from littermate hu-mice without pristane injection. Data shown is from four independent experiments (control n = 16; pristane n = 14). **P < 0.01; ***P < 0.001.
