Figure 2
From: A Novel Human Systemic Lupus Erythematosus Model in Humanised Mice
Lupus nephritis and pulmonary inflammation. (a) (Left) Kidney sections from hu-mice and NSG with or without pristane injection were H&E stained and pathologically evaluated. Scale bar represents 50 µm and images are representative from two independent experiments (control NSG n = 3; pristane NSG n = 3; control hu-mice n = 8; pristane hu-mice n = 12). (Right) Mean glomeruli area was measured from 50 random glomeruli from kidneys of each experimental animal (control NSG n = 3; pristane NSG n = 3; control hu-mice n = 5; pristane hu-mice n = 6). (b) Immunohistochemistry of human IgG and IgM on kidney sections from control and pristane-injected hu-mice Scale bar represents 50 µm and images are representative from two independent experiments (control n = 8; pristane n = 12). (c) Protein content in the urine of control and pristane-injected NSG, control and pristane-injected hu-mice at 10 weeks post-pristane injection was measured using Uristix reagent strips. Figure is from two independent experiments (control NSG n = 8; pristane NSG n = 3; control hu-mice n = 8; pristane hu-mice n = 7). (d) Lung sections were H&E stained and pathologically evaluated. Scale bar represents 200 µm and images are representative from two independent experiments (control n = 6; pristane n = 5). **P < 0.01.
